DNAI · LES AI · Lupus Eritematoso Sistémico

Clinical AI for lupus -
every criterion mapped.

Built from Dr. Erick Zamora's real lupus protocols. SLICC criteria, SLEDAI-2K activity, hydroxychloroquine monitoring — grounded in actual clinical decisions.

Request clinical access Read the brief
Proof of concept · In clinical evaluation · Dr. Erick Zamora
LES AI · Evaluación Clínica · Dr. Zamora En uso

Paciente con LES conocido

Carmen V. · 29 años · F · LES dx 2022 Control trimestral. Reporta fatiga aumentada y artralgia bilateral últimas 3 semanas.

Medicación actual

HCQ 400 mg/d · Prednisona 5 mg/d · Calcio + D3

Laboratorio

anti-dsDNA

↑ 340 UI

C3

↓ 62 mg/dL

C4

↓ 8 mg/dL

Proteinuria

0.4 g/24h

SLEDAI-2K · Actividad

Moderada · 8 pts Brote activo confirmado Artritis activa (4) + anti-dsDNA elevado (2) + hipocomplementemia (2). Umbral de brote alcanzado.
Revisión renal Proteinuria nueva · vigilancia Proteinuria 0.4 g/24h. No criterio nefritis aún, pero requiere seguimiento en 4 semanas.
Sin cambio HCQ Dosis ocular en rango seguro HCQ 5.0 mg/kg/d. Retinoscopia anual al día. No ajuste.

Manejo sugerido

Aumentar prednisona a 20 mg/d por 4 semanas, reducción gradual

Agregar azatioprina 100 mg/d si no mejora en 4 semanas

Control C3, C4, anti-dsDNA y orina en 4 semanas

Nefrólogo si proteinuria > 0.5 g/24h en próximo control

"Lupus is the diagnosis you have to earn. LES AI earns it alongside me — not instead of me. Every output is traceable back to a real clinical decision I have made."

Dr. Erick Zamora — Rheumatologist · Primary operator

2 of 7 products
in the DNAI
proof stack

Lupus is the hardest diagnosis to confirm — and the easiest to miss in follow-up.

Diagnostic complexity

SLICC criteria mapping takes time every consultation.

Eleven domains, multiple lab values, evolving presentation. LES AI maps criteria in real time so the physician focuses on the patient.

Activity monitoring

SLEDAI-2K scoring is manual and error-prone.

Calculating disease activity at every visit requires recall and arithmetic. LES AI computes it from the clinical record.

Drug monitoring

Hydroxychloroquine retinal toxicity windows are easy to miss.

Weight-adjusted dosing, ophthalmology intervals, G6PD screening. LES AI surfaces the right check at the right time.

Primera herramienta de IA para lupus en español · First AI tool for lupus in Spanish

En español: LES AI mapea los criterios SLICC 2012, calcula el SLEDAI-2K y verifica los parámetros de seguridad de la hidroxicloroquina en español. Construido desde protocolos reales de un reumatólogo en México, no desde literatura médica genérica.

Criterios SLICC · SLEDAI-2K · HCQ · Lupus · Español

In English: LES AI maps SLICC 2012 classification criteria, calculates SLEDAI-2K disease activity, and surfaces hydroxychloroquine safety parameters. Built from one rheumatologist's actual lupus clinical decisions — not general medical AI.

SLICC criteria · SLEDAI-2K · HCQ monitoring · Lupus · English

How LES AI works.

01

Clinical context from Dr. Erick's lupus practice.

LES AI is seeded from Dr. Erick Zamora's actual lupus case decisions — his threshold for treatment escalation, his protocol for nephritis workup, his HCQ dosing practice. Not a textbook; a physician's clinical memory.

02

Map the case against SLICC and SLEDAI-2K.

Enter the clinical presentation. LES AI maps SLICC classification criteria, computes SLEDAI-2K activity score, flags missing workup elements, and identifies organ involvement patterns.

03

Structured clinical output for the consultation.

Criteria count with evidence, activity score with interpretation, medication checks, suggested next steps. Structured for use in the consultation, not a chat response.

Clinical capabilities

What LES AI does today.

Current capabilities

  • SLICC 2012 classification criteria mapping from clinical presentation
  • SLEDAI-2K disease activity assessment with component breakdown
  • Hydroxychloroquine dosing verification (weight-adjusted, renal adjustment)
  • Ophthalmology monitoring interval tracking for HCQ
  • Complement consumption reasoning (C3, C4, CH50 patterns)
  • Lupus nephritis risk flagging from urinalysis and proteinuria trends
  • Flare recognition from lab trend and symptom pattern
  • Treatment escalation protocol suggestions (steroid, DMARD, biologic)

Access status

Proof of concept in active clinical evaluation.

LES AI is in clinical evaluation by Dr. Erick Zamora. Access available to rheumatologists and internists evaluating clinical AI for lupus practice.

Request clinical access Read the DNAI brief first

Part of the DNAI proof stack

LES AI RheumaAI RheumaScore ORVS Beach Science / clawRxiv STORM BiobadamexAI

Common questions.

Is this only for lupus?

Yes. LES AI is specifically built for Lupus Eritematoso Sistémico. It is seeded from Dr. Erick's lupus-specific clinical decisions, criteria mappings, and monitoring protocols. It does not generalize to other rheumatologic conditions — that specificity is what makes it useful.

Which scoring systems does it support?

SLICC 2012 classification criteria, SLEDAI-2K disease activity, and BILAG as secondary reference. HCQ safety parameters use ACR and AAO guidelines adapted to Dr. Erick's clinical thresholds.

How does it handle nephritis?

It flags nephritic patterns from proteinuria, urinalysis, and complement consumption. It references ISN/RPS classification criteria and Dr. Erick's referral thresholds. It does not replace a nephrology consultation — it surfaces when one is indicated.

What does it output?

SLICC criteria count with evidence per domain, SLEDAI-2K score with component breakdown, medication safety checks, organ involvement flags, and suggested next steps. Outputs are in Spanish or English.